Supporting and Miscellaneous Facilities
Molecular Modeling Capabilities
Computer based molecular modeling and molecular energy minimization
methods are having a major impact on areas such as drug design, visualization
of the structure of proteins and their complexes, and determination of
molecular conformations. The Department of Chemistry has excellent hardware
(14 Silicon Graphics servers and workstations, 3 Beowulf clusters, several dual processor Linux workstations for general use and 14 in research groups,
and
Office of Information Systems and Technology)
and software (Amber, InsightII/Discover, Gaussian 98 with GaussView, Spartan, Sybyl)
for visualization of molecular structure and interactions, and for quantum chemical,
molecular mechanics, and molecular dynamics calculations for research use.
Faculty and students in the Department are using these methods to conduct projects
as diverse as the determination of the structure of complex RNA viral genomes
(Dr. W. David Wilson) to
evaluating the factors that control biological activity of pharmaceutical
agents (Dr. David W. Boykin) and those that control motions in
biological molecules (Drs. Stuart
Allison and Dabney Dixon).
Georgia Combinatorial Chemistry Center
The Georgia Combinatorial Chemistry Center was established in
December 1997 at Georgia State University's Department of Chemistry under
the direction of
Dr. Binghe Wang
as an integral part of the
Biotechnology and Drug Design efforts. The
primary objective of the GCCC is to provide easy access to proprietary
and focused combinatorial libraries to the pharmaceutical, biotechnology,
agrochemical and environmental industries to help them discover new
leads in their respective areas of interest. The center also serves to
integrate the discovery of the local academic institutions thus maximizing
the availability of diverse libraries to our collaborating partners. Georgia
State University is proud to take a leading role in shaping this new
technology. The center intends to be a cost effective, business oriented
extension to corporate partners with an unique opportunity to benefit from innovative
and cutting-edge academic discoveries.
Crystallography
The
crystallographic facility at Georgia State University is under the
direction of Dr. Irene Weber
and supports macromolecular
crystallization experiments, X-ray diffraction measurements, and
computers for the determination and analysis of crystal structures.
The Crystallography facility includes a CrystalScore system for
automated analysis of crystallization experiments, and Silicon
Graphics and Sun workstations for computer graphic analysis. A linux
cluster is available for extensive computation.
Georgia State University and
Georgia Institute of Technology share
local X-ray diffraction equipment, a state of the art
R-Axis
system from Rigaku, which is located at Georgia Tech
and supervised by
Dr. Loren Williams.
Georgia Research Alliance
funds help support access to two synchrotron beamlines for high
intensity X-rays. Georgia State University is a member of
SER-CAT,
a team of researchers constructing a world class macromolecular
crystallographic facility at the
Advanced Photon Source (APS). The facility will be available to
all Georgia State researchers with a need for this advanced
instrumentation. Beamline X26C at the National
Synchrotron Light Source (NSLS) is also available for diffraction measurements.
Optical Spectrometers
- Cary 2200, 3E and 4 ultraviolet-visible spectrometers.
- Shimadzu 3101PC ultraviolet-visible-near infrared spectrophotometer.
- One Shimadzu 2401PC and three Shimadzu 1601PC ultraviolet-visible spectrophotometers.
- Perkin-Elmer SpectrumONE, 2000 and Paragon 1000 PC Fourier-transform infrared
spectrophotometers.
- Hitachi-Perkin Elmer MPF44a and SLM-8000C spectrofluorimeters.
- Photon Technology International QM1 fluorescence spectrophotometer.
- JASCO J-600 and J-710 circular dichroism spectrophotometers.
Research Equipment in the Center for Biotechnology and Drug Design
Preparative Biology
- Three Beckman L8-80 ultracentrifuges with rotors (Type 35, 45Ti, two 70Ti,
80Ti, VTi50, two VTi80, SW25-1, three SW28, SW50 and SW41).
- lyophilizers.
- DNA and peptide synthesis and analysis
Bioanalytical
- Biomek 2000 Laboratory Automation Workstation (automated reagent addition
and optical analysis for microtiter plates, Beckman).
- Beckman BioMek 2000 Workstation with M.J. Research Hot Bonnet Thermocycler.
- Molecular Devices SpectraMax (multiwavelength microtiter plate reader).
- Two Beckman P/ACE 5510 capillary electrophoresis instrument with diode array
detector.
- Beckman HLPC (125 solvent module) with 166 UV detector.
- EDS Fascalibur-3 Cell Sorter.
Research Equipment in the Combinatorial Chemistry Center
Synthesizers for small molecule organics and peptide libraries
- Two Advanced ChemTech 496 Omega automated synthesizers.
- Advanced ChemTech 384 HTS automated synthesizer
- Three Advanced ChemTech Labtech IV manual synthesizers
Analytical equipment/Spectrometers
- Nicolet 560 Magna FTIR spectrometer with a diamond compression cell for
polystyrene beads
- Two Hewlett Packard Model 1100 LCMS systems
- One HP Model 1100 HPLC
Automation/Liquid handling
- Three Gilson-215 Liquid handlers
- Beckman Multimek 96 automated pipettor
- Genevac HT-8 evaporator
- Genevac HT-4 evaporator
- Three Innovative Technologies Solvent Purification Systems
